Carbapenem-ResistantPseudomonas aeruginosa–Carrying VIM-2 Metallo-ß-Lactamase Determinants, Croatia

Carbapenem-Resistant Pseudomonas aeruginosa–Carrying VIM-2 Metallo-β-Lactamase Determinants, Croatia

To the Editor: Carbapenem-hydrolyzing enzymes of the VIM-type (six different variants are known: VIM-1, VIM-2, VIM-3, VIM-4, VIM-5, and VIM-6) are new molecular class B metallo-β-lactamases. These enzymes have recently been identified in carbapenem-resistant isolates of Pseudomonas aeruginosa and other gram-negative nonfermenters from European countries in the Koh et al., GenBank accession no. ...

Carbapenem-resistant Pseudomonas aeruginosa with acquired bla(vim) metallo-beta-lactamase determinants, Italy.

To the Editor: Acquired metallo-ß-lactamase determinants in Pseudomonas aeruginosa and other major bacterial pathogens are of concern for development of antimicrobial drug resistance. The carbapenemase and extended-spectrum cephalosporinase activity of metallo-ß-lactamases, as well as their resistance to ß-lactamase inhibitors, may severely limit the antimicrobial agents active against bacteria...

First occurrence of an Escherichia coli clinical isolate producing the VIM-1/VIM-2 hybrid metallo-beta-lactamase VIM-12.

Gram-negative bacteria producing VIM-type metallo-lactamases (MBLs) are increasingly isolated worldwide (8). The VIM group includes at least 13 variants, clustered into three evolutionary lineages, driven by VIM-1, VIM-2, and VIM-7 (www.lahey.org/studies/other.asp#table1). blaVIM-12 is a recently identified blaVIM-1/VIM-2 hybrid gene, originally found in 2005 in a Klebsiella pneumoniae clinical...

Identification of the first VIM metallo - β - lactamase producing multiresistant Aeromonas 1 hydrophila strain 2 3 Running title : VIM metallo - β - lactamase producing A . hydrophila 4 5

VIM-1 Metallo-β-lactamase in Acinetobacter baumannii

In 2004 and 2005, 5 metallo-beta-lactamase (MBL)-positive Acinetobacter baumannii isolates were found in 2 Greek hospitals. Isolates were unrelated and carried blaVIM-1 in a class 1 integron; bla(OXA-51-) and bla(OXA-58-like) carbapenemase genes were also detected. VIM-1 MBL in Acinetobacter spp. causes concern, given the increasing resistance of this species.